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KMID : 0362919870050010013
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Journal of the Korean Society for Therapeutic Radiology and Oncology
1987 Volume.5 No. 1 p.13 ~ p.21
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The Effect of Hyperthermia Combined with Radiation on Crypts of the Mouse Jejunum
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Bae Hoon-Sik
Park Charn-Il
Kim Jung-Jin
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Abstract
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The effect of local hyperthermia of 41 to 43℃ for 30 minutes on radiosensitivity of normal tissue was studied utilizing jejunal crypt microcolony assay. Hyperthermia of this range enhanced the radiation effect and the effect was mainly additive without significant effect on the slopes of cell survival curves.
At the isoeffect level of 20 microcolony formation, the thermal enhancement ratio was 1.02, 1.10 and 1.39 for 41˚, 42˚ and 43℃, respectively.
The distribution of microcolony formation along the circumference of jejunum was not uniform, having more colonies around the mesenteric border, and this suggests the effect of uneven cooling by blood circulation.
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KEYWORD
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Hyperthermia, Radiation, Jejunal crypt microcolony
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